Study on the reason of neonate death caused by septic shock and its high risk factors
LENG Jie
Abstract：Objective To investigate the reason of neonate death caused by septic shock and its high risk factors. Methods Seventy-three neonates with septic shock who were admitted into our hospital from August 2003 to June 2014 were enrolled in the study.The drug treatment,blood routine test,serum lactate levels,serum albumin, glucose,CRP were detected for all patients,besides, patient’ underlying diseases,vital signs, pathogens,usage of antimicrobial drugs, multiple organ dysfunction syndrome ( MODS) involved organ numbers, domestic pediatric critical illness scores ( PCIS) were retrospectively analyzed.Finally the reason of neonate death caused by septic shock and its high risk factors were analyzed by means of univariate analysis and multivariate logistic regression analysis.Results The mortality of neonates with septic shock was 52.08%.The results by univariate analysis showed that there was a significant difference in improper use of antibiotics between survival group and death group (χ2 =23.122, P <0.05),moreover, there were significant differences in serum lactate levels, albumin,glucose,MODS involved organ numbers,domestic PCIS between two groups ( P <0.05 or P <0.01) .The results by multivariate logistic regression analysis showed that serum lactate levels, albumin, MODS involved organ numbers and improper use of antibiotics were independent lethal risk factors for neonates with septic shock.Conclusion The mortality of neonates with septic shock is quite high,and serum lactate levels, albumin,MODS involved organ numbers and improper use of antibiotics are lethal risk factors,thus,the directive preventive and therapeutic measures should be taken in clinic.
Keywords：neonateseptic shockdeath statelethal factors
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3225-3227 )