The methylation status of TβRⅠ,Ⅱgene in endometrial cancer
YAN Xiangting
LIU Pan
LIN Huilan
Abstract：Objective To investigate the correlation between methylation of transforming growth factorβreceptorⅠ,Ⅱ(TβRⅠ,Ⅱ) gene and pathogenesis, development of endometrial cancer (EC).Methods The modified methylation specific PCR ( MSP) was used to detect the methylation status of TβRⅠ,Ⅱgene promoter in 60 cases of EC tissues and 60 cases of adjacent non-cancerous tissues.The correlation between the methylation of two gene promotors and clinical indexes was analyzed.Results The mathylation rate of TβRⅠin EC tissues and adjacent non-cancerous tissues was 75%(45/60) and 45% ( 27/60 ) , respectively. The methylation rate of EC tissues was significantly higher than that of adjacent non-cancerous tissues (χ2 =11.25, P <0.01).The mathylation rate of TβRⅡ in EC tissues and adjacent non-cancerous tissues was 68.3%(41/60) and 36.7%(22/60),respectively.The methylation rate of EC tissues was significantly higher than that of adjacent non-cancerous tissues (χ2 =12.06, P <0.01 ) .However there was no correlation between the methylation of two gene promotors and clinical indexes ( P >0.05).Conclusion The methylation of TβRⅠand TβRⅡpromoters may be correlated to the pathogenesis of EC.
Keywords：endometrial cancermethylationTβRⅠTβRⅡ
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3215-3218 )