The changes and clinical significance of plasma vascular vWF-CP and GDF15 levels in patients with coronary heart diesase

ZHANG Yingyan; GAO Mingming; XU Jingj ing

doi:10.3969/j.issn.1002-7386.2015.20.006

Abstract：Objective To investigate the changes and clinical significance of von Willebrand factor cleaving protease (vWF-CP) and growth differentiation factor-15 (GDF15) levels in patients with coronary heart disease (CHD).Methods One hundred and four patients with CHD who were treated in our hospital from February 2012 to July 2014 were enrolled in the study,including 48 patients with stable angina pectoris (SAP group), and 56 patients with acute coronary syndrome (ACS group) ,at the same time, the other 43 patients with similar angina pectoris were served as control group.The plasma levels of vWF-CP, GDF15 and biochemical parameters including total cholesterol ( TC) ,low density lipoprotein cholesterol ( LDL-C) , high density lipoprotein cholesterol ( HDL-C ) were detected for the three groups.R seults There were no significant differences in the levels of TC,LDL-C,HDL-C,Cr and AST between SAP group,ACS group and control group ( P >0.05). The plasma vWF-CP in control group was (612.18 ±24.07) pg/ml, which was significantly higher than that of SAP group and ACS group,moreover, plasma vWF-CP in SAP group was (373.13 ±24.09)pg/ml,which was significantly higher than that of ACS group (276.39 ±23.18)pg/ml ( P <0.05).The plasma GDF15 in control group was (1.42 ±0.37)ng/ml, which was significantly lower than that in SAP group or ACS group ,however,plasma GDF15 in SAP group was (7.93 ±0.67) ng/ml,which is significantly lower than that of ACS group (100.2 ±0.92)ng/ml ( P <0.05).The plasma levels of vWF -CP were negatively correlated to those of GDF15 ( r =-0.702, P <0.05).Conclusion There is a correlation between plasma vWF-CP and vascular GDF15 in patients with CHD,which can be used to predict the risk of patients with CHD in clinic.