Effects of mifepristone combined with laparoscopic surgery on serum macrophage migration inhibition factor, ;vascular endothelial growth factor and its receptor in patients with endometriosis
YANG Qingchun
Abstract：Objective To investigate the effects of mifepristone combined with laparoscopic surgery on serum macrophage migration inhibition factor ( MIF ) , vascular endothelial growth factor ( VEGF ) and its receptors ( VEGF1, VEGF2) in patients with endometriosis.Methods A total of 90 patients with endometriosis who were admitted into our hospital from January 2012 to January 2015 were randomly divided into observation group ( n =45) and control group ( n =45).The patients in control group were treated by laparoscopic surgery, however, the patients in observation group,on the basis of control group.were treated by mifepristone,with a treatment course of 6 months for both groups.After treatment, the therapeutic effects, one-year conception rate, serum levels of hs-CRP, CA125, MIF, VEGF, VEGFR1, VEGFR2 and postoperative relapse rate were observed and compared between two groups.Results The total effective rates in observation group were significantly higher than those in control group( 93.33%vs 75.56%, P <0.05).The one-year conception rate in observation group was significantly higher than that in control group (33.33%vs 17.78%, P <0.05).After treatment, the pelvic mass volume, serum levels of hs-CRP, CA125, MIF, VEGF, VEGFR1, VEGFR2, EHP-5 scores were obviously improved,as compared with those before treatment in both groups ( P <0.05), moreover, the improvement degree in observation group was superior to that of control group ( P <0.05).All the patients were followed up for 1 year, the relapse rate in observation group was significantly lower than that of control group (6.67% vs 26.67%, P <0.05).Conclusion The laparoscopic surgery combined with mifepristone is effective in treating endometriosis, which can obviously increase conception rate, decrease postoperative relapse rate and improve life quality of patients, and its action mechanism may be related to the down-regulation of expression levels of MIF, VEGF, VEGFR1, VEGFR2.
Keywords：endometriosislaparoscopic surgerymifepristonemacrophage migration inhibition factorvascular endothelial growth factorvascular endothelial growth factor receptor 1vascular endothelial growth factor receptor 2
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2900-2903 )