Correlation between resveratrol and the proliferation and apoptosis in salivary adenoid cystic carcinoma cell line ;ACC-M in vitro
Abstract：Objective To observe the effect of resveratrol on human salivary adenoid cystic carcinoma cell line-ACC-Min vitro.Methods The ACC-M cells were treated with resveratrol at 12.5,25,50,100, 200μmol/L for 24h, 48h, 72h,respectively.The proliferation and apoptosis of ACC-M cells were observed by MTT assay, inverted microscopy, light microscopy,flow cytometry.Results Resveratrol inhibited the proliferation of ACC-M cells in a dose and time dependent manner.The highest inhibition rate was 92.6%.Resveratrol induced apoptosis and necrosis of ACC-M cells,and the apoptotic rate was positively correlated to the action time and action concentration of resveratrol ( P <0.05).Conclusion Resveratrol can inhibit the proliferation of ACC-M cells by inducing apoptosis and/or necrosis of the cells.
Keywords：resveratrolsalivary adenoid cystic carcinomaproliferationapoptosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2897-2899 )