The role of serum adiponectin in type 2 diabetes mellitus complicated by gallstone

doi:10.3969/j.issn.1002-7386.2015.19.003

Abstract：Objective To investigate the role of serum adiponectin in the pathogenesis of gallstones,and to explore the correlation between serum adiponectin and glycosylated hemoglobin as well as blood fat levels.Methods The patients with simple diabetes mellitus were selected from the patients with type 2 diabetes mellitus as group D ( n =29),and the patients with diabetes mellitus complicated by gallstone were selected as group D+G ( n =27),and the other 34 healthy subjects were served as control group.The fasting vein blood specimens (3ml) were taken in all the subjects at 10~12 hours after fasting, then the related parameters were detected.The one-factor analysis of variance was used to compare these parameters including patient’s age,disease duration,BMI,HbA1c content,the levels of blood-fat,TG,,CH,HDL,LDL among the three groups, moreover, multiple correlation regression was used to analyze the correlation between serum adiponectin and these parameters. Results The serum levels of adiponectin in control group were significantly higher than those in group D ( P <0.05),which were also significantly higher than those in group D+G ( P <0.05).Moreover, the serum levels of adiponectin in group D were significantly higher than those in group D+G ( P <0.05).The adiponectin content in serum was positively correlated to that of HDL ( r =0.90),however,which was negatively related with BMI and the percentage of HbA1c ( r =-0.77, r =-0.72,respectively) .Conclusion The trend that the patients with diabetes mellitus are liable to be complicated by gallstone is related with the low levels of serum adiponectin,furthermore, the serum levels of adiponectin in patients with type 2 diabetes mellitus complicated by gallstone are correlated to BMI, percentage of HbA1c,HDL content.