Therapeutic effects of rosuvastatin combined with ezetimibe on coronary heart disease complicated by early diabetic nephropathy

doi:10.3969/j.issn.1002-7386.2015.13.006

Abstract：Objective To observe the therapeutic effects of rosuvastatin combined with ezetimibe on coronary heart disease complicated by early diabetic nephropathy in order to look for more effective therapy to prevent the pathogenesis of acute cardiovascular events and end-stage nephropathy. Methods Eighty patients with stable angina pectoris complicated by early diabetic nephropathy diagnosed in Hebei Province Geriatric Hospital from July 2013 to January 2014 were enrolled in the study,including 42 male patients and 38 female patients,whose age was over 60 years and whose blood sugar was controlled effectively,without blood relationship each other. There patients were randomly divided into observation group and control group,with 40 patients in each group. On the basis of routine therapy,the patients in control group were treated by rosuvastatin 10mg/ d,however,the patients in observation group,on the basis of routine therapy,were treated by rosuvastatin 10mg/ d +ezetimibe 10mg/ d. Results After 12-week treatment,the levels of LDL in observation group were significantly decreased,as compared with those in control group( P < 0. 01). The angina pectoris attacks time in control group was obviously shortened, and the attacks frequency of angina pectoris was obviously decreased,as compared with that before treatment( P < 0. 05). After 12-week treatment,the attacks frequency of angina pectoris in observation group was significantly decreased,as compared with that in control group( P < 0. 05). After 12 - week treatment,the UAFR levels in both groups were significantly decreased,as compared with those before treatment( P < 0. 01),moreover,the decrease degree in observation group was more obvious than that in control group( P < 0. 05). Howevrer there were no significant differences in the levels of serum creatinine,serum creatine kinase,alanine aminotransferase,aspartate aminotransferase before and after treatment between two groups( P > 0. 05). Conclusion In the treatment of coronary heart disease complicated by early diabetic nephropathy,the combined application of rosuvastatin with ezetimibe can significantly reduce the frequency and duration of angina pectoris attacks,and can promote the improvement of myocardial ischemia,at the same time,can decrease microalbuminuria and reduce more effectively the levels of LDL and TC,without increasing the incidence of adverse events,with better safety.