Expression and significance of Maspin and uPA protein in endometrial carcinoma
LI Meiyan
Abstract：Objective To investigate the expression of Maspin in endometrial tissue of patients with endometrial carcinoma and its relationship with urokinase-type plasminogen activator(uPA)protein. Methods The expression levels of Maspin and uPA protein were detected by immunohistochemicstry(SP)in 50 cases of endometrial carcinoma,50 cases of atypical endometrial hyperplasia and 30 cases of normal endometrial tissues at proliferative phase. The correlation of expression of Maspin and uPA protein between Maspin and uPA and their effects on prognosis of patients with endometrial carcinoma were analyzed. Results The positive expression rates of Maspin protein and uPA protein were closely related with surgical pathological staging,the depth of myometrial infiltration and lymph node metastasis( P < 0. 05),furthermore,the expression of uPA protein was negatively related with that of Maspin protein( r = - 0. 341,P < 0. 05). Conclusion Maspin protein and uPA protein play an important role in the pathogenesis and development of endometrial carcinoma,therefore,the combination detection of expressions of Maspin and UPA protein may contribute to evaluating the malignant degree and prognosis of endometrial carcinoma.
Keywords：endometrial carcinomaMaspin proteinuPA proteinimmunohistochemistry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1938-1940 )