Clinical study on the expression and correlation of EGFR,Ki-67 in three negative breast cancer
LI Yansong
Abstract：Objective To investigate the expression and clinical significance of EGFR,Ki-67 in three negative breast cancer(TNBC)and its relationship with the clinicopathological characteristics as well as the correlation between endothelial growth factor receptor(EGFR)and Ki-67 gene expression. Methods The clinicopathological characteristics of 67 cases of human TNBC and 125 cases of non TNBC(NTNBC)were retrospectively analyzed,and the expression levels of EGFR,Ki-67 in the two groups were detected by immunohistochemistry,moreover,the correlation between EGFR and Ki-67 gene expression was analyzed. Results The positive expression rate of EGFR in TNBC group was 89. 6% ,however,which was 57. 6% in NTNBC group,there was a significant difference between two groups( P < 0. 05). The expression of EGFR in TNBC group was not related with patient’s age,tumor’s size,lymph node metastasis and histological grade,however,which was correlated to pathological type. The positive expression rate of Ki-67 in TNBC group was 92. 5% ,however,which was 66. 4% in NTNBC group,there was a significant difference between two groups( P < 0. 05). The expression of Ki-67 in TNBC group was not correlated to patient’s age,tumor’s size,lymph node metastasis,histological grade and pathological type. Conclusion The high-expression of EGFR and Ki-67 appears in TNBC,which suggests its high malignant degree,greater invasion and poor prognosis,therefore,EGFR and Ki-67 can be regarded as important reference indexes for evaluating the prognosis of TNBC.
Keywords：triple negative breast carcinomaendothelial growth factor receptorKi-67immunohistochemistry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1936-1938 )