Correlation between the expression of COX-2 or Her-2/neu and prognosis of pancreatic carcinoma

SU Chunyong; YANG Xiaoguang

doi:10.3969/j.issn.1002-7386.2015.13.002

Abstract：Objective To investigate the expression of COX-2 or Her-2 / neu in pancreatic carcinoma,and to explore the correlation between their expressions and clinical characteristics of pancreatic carcinoma as well as the relationship between them. Methods The expression levels of COX-2 and Her-2 / neu were detected by immunohistochemistry(RT-QPCR)in 50 cases of primary pancreatic carcinoma and 36 cases of tumor adjacent tissues,and microvessel density(MVD)was calculated. The correlation between their expressions and clinical pathological parameters of pancreatic carcinoma as well as the relationship between the two factors were analyzed. Results The overexpression of COX-2 and Her-2 / neu appeared in pancreatic carcinoma tissues,furthermore,the overexpression of COX-2 was closely correlated to the proliferative activity, infiltration and metastasis,TNM clinical staging,one-year survival rate of pancreatic carcinoma( P < 0. 05),however,which was not related with patient’s age,sex,anatomical site and histological grade of pancreatic carcinoma. The high-expression of Her-2 / neu was closely correlated to histological grade ,TNM clinical staging and infiltration and metastasis of pancreatic carcinoma( P < 0. 05),however,which was not related with patient’s age,sex,anatomical site and proliferative activity of pancreatic carcinoma. The expression of COX-2 was positively correlated to that of Her-2 / neu in pancreatic carcinoma, moreover,both of them were positively related with MVD( P < 0. 05). The positive expression rates of COX-2 and Her-2 / neu in patients with prognosis ≤1 year were significantly lower than those of patients with prognosis > 1 year( P < 0. 05). Conclusion The expression of COX-2 is positively correlated to that of Her-2 / neu in pancreatic carcinoma,and combination detection of COX-2 with Her-2 / neu may play a certain role in the diagnosis,treatment and prognosis of pancreatic carcinoma.