Analysis for gene expression profiling of Duchenne muscular dystrophy
Abstract：Objective To explore the pathogenesis of Duchenne muscular dystrophy (DMD) by integrating microarray data related with DMD from Gene Expression Omnibus (GEO)database and to analyze these data.Methods The differential expression gene analysis and pathway enrichment analysis were performed by means of the two datasets,GSE6011 and GSE3307 that were downloaded from GEO database.Results In the specimens before symptom onset were identified as 41 pathways that were rich with differential expression genes and 33 pathways in the specimens after symptom onset in which 70% of pathways were shared in both phases,furthermore,most of them were correlated to immunity.Further investigation showed that presymptomatic patients were superior to post -symptomatic patients in the respects of muscle regeneration and calcium homeostasis maintaining in myocardial cell.Neuronal nitric oxide synthase (NOS ),dihydropyridine receptors (DHPR),sarcoplasmic /endoplasmic reticulum calcium ATPase (SERCA)and phospholamban (PLN)might become potential targets for molecular diagnostic tests and treatment of DMD in the future.Conclusion The experimental results provide a basis for understanding further the pathogenesis of DMD.
Keywords：Duchenne muscular dystrophyexpression profilingdysfunctional pathwaydisease progressionmechanism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1461-1465 )