Expression and significance of CerbB-2,MDR1/P-gp protein in sigmoid colon mucinous adenocarcinoma

doi:10.3969/j.issn.1002-7386.2015.10.003

Abstract：Objective To investigate the correlation between the expression of CerbB-2 and MDR1 /P-gp in sigmoid colon mucinous adenocarcinoma and clinical prognostic data.Methods The expression levels of CerbB-2 and MDR1 /P-gp were detected by immunohistochemistry and tissue microarray technique in 86 cases of sigmoid colon mucinous adenocarcinoma tissues.Results The positive expression rate of CerbB-2 in patients at stage Ⅲ was 76.19%(16 /21),which was significantly higher than that of patients at stage Ⅰand stage Ⅱ.The positive expression rate of CerbB-2 in patients with axillary lymph node metastasis was 65.71%,which was significantly higher than that (37.25%)of patients without axillary lymph node metastasis (P <0.05).However there was no significant difference in the positive expression rate of MDR1 /P-gp between stage Ⅲ and stage Ⅰ,stage Ⅱ(P >0.05).The positive expression rate of MDR1 /P-gp in patients with axillary lymph node metastasis was 62.85%,which was significantly higher than that (29.41%)of patients without axillary lymph node metastasis (P <0.05).Both positive expressions of MDR1 /P-gp and CerbB-2 accounted for 72.97%(27 /37),however,the negative expression of CerbB-2 accounted for 54.05%(20 /37),there was significant difference between two groups (P <0.01 ). However there was no significant difference between the expression of CerbB-2 and MDR1 /P-gp in different size tumors (P >0.05).Conclusion The positive expression of CerbB-2 and MDR1 /P-gp plays a certain role in the pathogenesis of multidrug resistance of sigmoid colon mucinous adenocarcinoma,thus combined detection of CerbB-2 and MDR1 /P-gp is helpful to provide basis for the comprehensive treatment of sigmoid colon mucinous adenocarcinoma.