Therapeutic effects of combination of recombinant human brain natriuretic peptide,dopamine and furosemide on cardiorenal syndrome
Abstract：Objective To observe the therapeutic effects of combination of recombinant human brain natriuretic peptide,dopamine and furosemide on cardiorenal syndrome.Methods Two hundred patients with cardiorenal syndrome were randomly divided into control group (routine treatment) and treatment group (routine treatment plus recombinant human brain natriuretic peptide,dopamine and furosemide intravenous drip ),with a treatment course of 7 days.Echocardiography was performed before and after treatment, the levels of N terminal pro-brain natriuretic peptide ( Nt-proBNP),serum creatinine (SCr),blood urea nitrogen (BUN) and uric acid (UAC) were detected and creatinine clearance rate was calculated according to Cockcroft-Gault formula before and after treatment.The cardiac function improvement state was evaluated according to the degree of dyspnea, pulmonary rales,heart rate,respiratory rate,body weight,urine volume,6 minutes walking distance,BNP and the index of echocardiography (LVEDd,LVEF,SV).The renal function improvement state was evaluated according to creatinine clearance rate.Results The general situation was obviously improved,as compared with that in control group,the levels of SCr,Nt-proBNP were decreased,however,the levels of CCr,urine volume, LVEF and SV were increased,the cardiac and renal function were significantly improved in treatment group , as compared with those in control group( P <0.05). Conclusion The combination application of recombinant human brain natriuretic peptide,dopamine and furosemide can obviously improve cardiorenal function,which is beneficial to the treatment of cardiorenal syndrome.
Keywords：recombinant human brain natriuretic peptidedopaminefurosemidecardiorenal syndrome
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1304-1307 )