Expression and significance of Bcl-2 Bax in oral leukoplakia
MAN Yi
ZHONG Liangjun
XU Weiwei
Abstract：Objective To investigate the expression and significance of apoptosis -related protein Bcl-2,Bax in oral leukoplakia (OLK),and to explore the mechanism of pathogenesis and cancerization of oral leukoplakia.Methods The expression levels of Bcl-2 and Bax were detected by immunohistochemistry in 29 cases OLK and 25 cases of healthy oral mucosa.Results The apoptosis indexes (AI) of OLK epithelial cells in simple hyperplasia, dysplasia ( mild,moderate, severe degrees ) were significantly increased, as compared with those in normal mucosa.In OLK epithelium, the overexpressions of Bcl-2,Bax in positive cells were observed,and the intensity and distribution of apoptosis-related protein were significantly changed.Conclusion In precancerous lesions,Bcl-2 may promote the progression of canceration of hyperplastic tissue, enhance the effects of Bax in inducing cell apoptosis,moreover,the effects of apoptosis-related proteins are not only cooperative but also restrict each other.
Keywords：leukoplakiaapoptosis ptoteinBcl-2Bax
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1297-1300 )