Analysis for pharmacokinetics and therapeutic efficacy of netilmicin by means of intravenously guttae in elderly patients with chronic obstructive pulmonary disease
CHEN Kun
XIAO Yinglin
Abstract：Objective To investigate the distribution and pharmacokinetics of ) netilmicin ( NTM ) in lower respiratory tract of elderly patients with chronic obstructive pulmonary disease ( COPD ) by means of intravenously guttae administration ( iv gtt) ,and to analyze its therapeutic effect and adverse reactions.Methods The concentrations of NTM in bronchial secretions,pulmonary alveolus solution and serum were detected by fluorescence polarization immunoassay ( FPIA) , using urea as diluted internal standard instead of pulmonary alveolus solution.Results The pharmacokinetic parameters in patents who received intravenously guttae with netilmicin 7.0mg/kg were as follows: the maximum concentration ( Cmax) of NTM was (26.73 ±4.96)mg/L,elimination half life was 3.95h,the maximum concentration of NTM in pulmonary alveolus solution was (7.75 ±2.12) mg/L,which was equal to 30%of serum Cmax.However there was no correlation between the drug concentration in bronchial secretions and blood drug level.The drug concentration in pulmonary alveoli was higher than MIC value of common pathogen of pneumonia by means of intravenously guttae administration.The toxicities of nerve, liver and kidney were not found in all the patients after successive administration for 7 days.Conclusion The intravenously guttae way is more suitable for the treatment of COPD in elderly patients,with longer dosing interval,without increasing side effects.
Keywords：intravenously guttae administrationnetilmicinpulmonary diseaseobstructiveclinical effectpharmacokinetic
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1148-1151 )