Effects of omeprazole on the oxidative stress in rat models with esophageal mucosal injury induced by acid reflux

doi:10.3969/j.issn.1002-7386.2015.07.008

Abstract：Objective To observe the effects of omeprazole on the oxidative stress in rat models with esophageal mucosal injury induced by acid reflux .Methods Healthy male SD rats weighted 220~250 g were randomly divided into 5 groups:sham-operation group (sham group),gastroesophageal reflux group (model group),omeprazole low-dose,median-dose and high-dose groups .The rat models with reflux esophagitis were induced by acid reflux .The pathological changes on esophageal mucous membrane were examined by naked eye .The contents of MDA ,NO and the activities of SOD and NOS were detected.Results The esophagus of rat presented erythroid and lustrous ,with glossy mucosal membranes in sham group .As compared with that in sham group , the esophagus presented light white and esophageal mucous membrane became rough , thicken,grey plaque-like proliferation in model group .As compared with those in model group ,these changes mentioned above were significantly alleviated in omeprazole treatment groups .As compared with those in sham group ,the contents of MDA ,NO and activity of NOS were significantly increased ,however,the activity of SOD was significantly decreased in model group .As compared with those in model group ,the contents of MDA,NO and activity of NOS were significantly decreased ,however,the activity of SOD was significantly increased in omeprazole treatment groups .Conclusion Omeprazole can obviously decrease the esophageal mucosal injury induced by acid reflux through decreasing the contents of MDA ,NO and activity of NOS,and increasing the activity of SOD .