Effects of Toutongning capsule on the behaviors and symptoms of ratsw ith migraine
KUANG Deli
FU Yansong
LIU Bin
Abstract：ObjectiveToobservetheeffectsofToutongningcapsuleonthebehaviorsandsymptomsofratswith migraine.Methods Seventy-two SD rats were randomly divided into 6 groups: normal control group,migraine model group, Sibelium treatment group,Toutongning high-dose group,Toutongning median-dose group,Toutongning low-dose group,with 12 rats in each group.The animal models with migraine were established by subcutaneous injection with NTG.The rats in normal control group were given 0.9%sodium chloride solution by subcutaneous injections.The appearing time and disappearing time of redness in both ears of rats after the animal models were established, terminal time of scratching head, climbing cage frequency were observed and recorded in the 6 groups.Results There were no significant differences in the terminal time of redness in both ears of rats, terminal time of scratching head and climbing cage frequency between Toutongning high-dose group,Toutongning median-dose group and Sibelium treatment group ( P >0.05),however,there were significant differences between Toutongning low-dose group and Sibelium treatment group ( P <0.05).Conclusion Toutongnning capsule can improve the behavior and symptom of rats with migraine caused by nitroglycerin,and the therapeutic effects of high-dose and median-dose Toutongning capsule are more obvious.
Keywords：migraineToutongnningcapsuleanimalmodelethologysemeiology
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 819-822 )