Expression and clinical significance of DKK-1 in serum and hydrothorax of patients with lung cancer
Abstract：ObjectiveToinvestigatetheexpressionlevelsofDickkopf-1(DKK-1)inserumandhydrothoraxof patientswith lung cancer, and to explore its clinical diagnostic value .Mtehods Eighty -two patients with lung cancer ( observation group) and 38 patients with pulmonary benign lesion ( control group ) who were admitted into department of respiratory disease of our hospital from March 2011 to April 2012 were enrolled in the study.The levels of DKK-1 in serum and hydrothorax were detected by enzyme-linked immunosorbent assay ( ELISA) for both groups.Resu lts The levels of DKK-1 in observation group were significantly increased,as compared with those in control group ( P <0.05).The expression levels of DKK-1 in serum were positively correlated to those in hydrothorax ( r =0.72, P <0.05) .Both sensitivity and specificity of DKK-1 in diagnosis of lung cancer were higher.The levels of DKK-1 were obviously decreased in patients with NSCLC after two treatment courses by routine chemotherapy ( P <0.05).Conclusion DKK-1 is hopeful to become an new target point for diagnosis and treatment of lung cancer.
Keywords：DKK-1lungneoplasmsenzyme-linkedimmunosorbentassaybonemetastasis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 815-818 )