Experimental study of the protective effect of Edaravone on brain after traumatic brain injury
Abstract：Objective To investigate the possible action mechanism of protective effect of Edaravone on brain after traumatic brain injury .Methods The middle degree closed diffused craniocerebral injury models in rats were established by improved Marmarou's method.After the models were successfully established ,the free radical in cortex of the rats ,Cyt-c and apoptosis cell numbers were detected and observed dynamically by TAB ,immunohistochemry,TUNEL,respectively.Results Edaravone could decrease obviously the levels of free radical ,the expression of Cyt-c and apoptosis nerve cells after traumatic brain injury Conclusion Edaravone is effective in treating traumatic brain injury ,and one of action mechanisms is to reduce generation of free radical,inhibit opening of mitochondrial permeability transition pore (MPTP),reduce releasing of Cytc,and then decrease nerve cell apoptosis .
Keywords：traumatic brain injuryEdaravonefree radicalmitochondrial permeability transition poreCytcapoptosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 353-355 )