Prognosis assessment value of N-terminal pro-B-type natriure tic peptide for noncardiac severe patients in intensive care unit
LI Baolaing
SU Hua
CHEN Chen
Abstract：Objective To investigate whether plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is an independent risk factor for noncardiac severe patients in intensive care unit ( ICU ) .Methods A prospective observational study was performed in which 152 noncardiac severe patients in ICU were enrolled .The patients ’ age, sex, basic data, APACHEⅡscores were collected,the patients’ NT-pro-BNP levels were detected at day 1,2,5 after admission to ICU and 28-day mortality was recorded.Results The 28-day mortality of the patients was 39.8%(61/152).The plasma NT-pro-BNP levels (pg/ml) and APACHE Ⅱscore in death group were significantly higher than those in survival group ( P <0.05) at the first day of admission to ICU.There was a correlation between plasma NT-pro-BNP levels and APACHE II score,moreover, which was independent risk factor of influencing 28-day mortality of noncardiac severe patients in ICU .The area under receiver operating characteristic curve ( ROC curve) of NT-pro-BNP and APACHE Ⅱ score were 0.731 and 0.714,respectively. NT-pro-BNP was better than APACHE Ⅱ in evaluating patients ’ prognosis , however , there was no significant difference between them ( P >0.05).The optimized critical value of plasma NT-pro-BNP was 5 003.39pg/ml,furthermore,the survival rate in NT-pro-BNP<5 003pg/ml group was significantly higher than that NT-proB-NP>5 003pg/ml group (χ2=32.1, P<0.01).Conclusion The NT-pro-BNP>5 003pg/ml of noncardiac severe patients in ICU is an independent risk factor in evaluating patients’ prognosis.
Keywords：N-terminal pro-B-type natriuretic peptideAPACHE Ⅱ scoreICUnoncardiogenic severe patientsprognosis assessment
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 343-345 )