Effects of Tongxinluo capsule on the expression of FN and LN in retina of diabetic mice
Abstract：Objective To explore the effect of Tongxinluo capsule on the expression of fibronectin ( FN) and laminin (LN) in retina of KK/Upj-Ay mice.Methods Forty KK/Upj-Ay mice were randomly divided into 4 groups:model group, Tongxinluo low-dose group (1g/kg),median-dose group (2g/kg),high-dose (4g/kg)group.The mice were given medicines intragastrically once a day for consecutive 12 weeks.The other 10 C57BL/6 mice were enrolled as control group .The expression levels of FN and LN mRNA in retina were detected by Real time PCR ,and the contents of protein were determined by Western blotting .Results As compared with those in control group ,the expression levels of LN ,FN mRNA and protein in retina in model group were significantly increased ( P <0.05),however,which in Tongxinluo low-dose group,median-dose group,high-dose group were significantly decreased ,as compared with those in model group ( P <0.05).Conclusion Tongxinluo capsule may improve diabetic retinopathy by inhibiting the expression of LN and FN in retina tissue of diabetic mice.
Keywords：Tongxinluo capsulediabetic retinopathyfibronectinlaminin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 174-176 )