Study on the metabolic changes in hippocampal head,body and tail during normal brain aging by means of 1H-MRS technique

doi:10.3969/j.issn.1002-7386.2015.02.002

Abstract：Objective To investigate the regulation of material metabolism changes in different regions of bilateral hippocampus during normal brain aging through proton magnetic resonance spectroscopy (1H-MRS) technique.Methods One hundred and twenty-one right handedness healthy volunteers were enrolled in the study ,according to their age who were divided into youth group (age range:20~44yr, n =47),middle-aged group (age range:45~59yr, n =40),older age group (age range:60~79yr, n =40),all the volunteers were examined by MRI and MRS ,the concentration ratio of metabolite in different regions of bilateral hippocampus ( NAA/Cr and Cho/Cr ) was automatically measured .The differences of the parameters in different sex ,different side and different age groups were statistically analyzed .Results There was a significant difference in the concentration ratio of NAA/Cr in bilateral hippocampal head between older age group and youth group and between older age group and middle age group ( P <0.05).There was a significant difference in the concentration ratio of NAA/Cr in bilateral hippocampal body-region 1,left hippocampal body-region 2 and left hippocampal body tail between older age group and youth group ( P <0.05),however,there was no significant difference in the ratio of Cho /Cr in hippocampal head,body (region 1 and region 2) and tail among the three groups ( P >0.05).There was no significant difference in the ratio of NAA/Cr,Cho/Cr in different regions of bilateral hippocampus ( P >0.05).There was no significant difference in the ratio of NAA/Cr,Cho/Cr in hippocampal head ,body (region 1 and region 2) and tail among the three groups ( P >0.05). Conclusion There is significant difference in the ratio of NAA/Cr in different regions of bilateral hippocampus among different age groups,howevere,there is no significant difference in the ratio of NAA/Cr.Moreover there is no significant difference in ratio of NAA/Cr,Cho/Cr in different regions of bilateral hippocampus between males and females and between left side and right side .