Correlation between IL-8 as well as its receptor gene polymorphism and susceptibility to pulmonary tuberculosis

doi:10.3969/j.issn.1002-7386.2015.01.004

Abstract：Objective To explore the relationship between IL-8 +781 C/T as well as its receptor CXCR 1 +2608 G/C gene polymorphisms and susceptibility to pulmonary tuberculosis .Methods The case control study was used , and genotyping was performed in IL-8 +781C/T locus and CXCR1 +2608G/C locus in 78 patients with pulmonary tuberculosis (case group) and 97 healthy subjects (control group) by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP) ,then the correlation between polymorphism in the two gene locus and pathogenesis of pulmonary tuberculosis was analyzed by χ2 test.Results The distribution frequency of CC ,CT and TT genotype in IL-8 +781C/T locus was 82.0%, 15.4%,2.6%,respevtively in case group,which was 85.6%,13.4%,1.0%,respectively in control group,there was no significant difference in the distribution frequency between two groups (χ2 =0.72, P >0.05),at the same time,there was no significant difference in the distribution frequency of C ,T allele between two groups (χ2 =0.68, P >0.05).The distribution frequency of GG,GC and CC genotype in CXCR1 +2608G/C locus was 83.3%,15.4%,1.3%,respectively in case group, which was 79.4%,20.6%,0%,respectively in control group ,there was no significant difference in the distribution frequency between two group (χ2 =1.89, P >0.05),meanwhile,there was no significant difference in the distribution frequency of G ,C allele between two group (χ2 =0.18, P >0.05).Conclusion The single nucleotide polymorphism (SNP) in IL-8+781C/T locus and CXCR1+2608G/C locus is not correlated to susceptibility to pulmonary tuberculosis .