Effect of exogenous carbon monoxide on myocardial damage induced by ischemia reperfusion in rats
Abstract：Objective To investigate the protective effect of exogenous carbon monoxide ( CO ) on myocardium damage induced by ischemia-reperfusion (IR) in right hind limb of rats,and to explore its action mechanism.Methods Twenty-two Sprague-Dawley rats were randomly divided into three groups:IR group ( n =10 ) ,IR +CO group ( n =10 ) and sham-operation group ( n =2).The changes of myocardial structure and transverse striation were observed ,and the apoptosis rate,expression levels of Bax and Bcl-2 in myocardial tissues,the activities of lactate dehydrogenase (LDH) and creatine kinase isoenzyme ( CK-MB ) in serum were detected .Results The expression levels of Bcl-2 in IR +CO group were significantly higher than those in IR group ,however,the other indexes in IR +CO group were obviously lower than those in IR group,with milder myocardial damage in IR +CO group.Conclusion The exogenous carbon monoxide can mitigate myocardial damage induced by ischemia reperfusion in rats ,its action mechanism may be related with suppressing neutrophil aggregation in myocardial tissue .
Keywords：carbon monoxideischemia-reperfusion injurymyocardiumneutrophil
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 10-12 )