Experimental study on topiramate-induced embryonic toxicity in mice and intervention effect of folic acid

doi:10.3969/j.issn.1002-7386.2014.24.005

Abstract：Objective To observe the embryonic toxicity induced by topiramate (TPM) in pregnant mice,and to explore the intervention effect of folic acid (FA).Methods The mice were randomly divided into 5 groups,with the ratio of females/males being 2∶1,blank control group,TPM low-dose group,TPM high-dose group,TPM low-dose +FA group,TPM high-dose +FA group,with 20 mice in each group.The female mice were given drugs at 2 days after grouping until the end of pregnancy .The indexes including reproductive ability , growth and development , deformity of mice were observed for the five groups.Results As compared with that in blank control group , the live fetus rate was significantly decreased , however absorption fetus rate and dead fetus rate were significantly increased in TPM high-dose group and TPM high-dose +FA group ( P <0.01).As compared with those in blank control group ,the body weight,body length and tail length of fetal mice were significantly decreased in TPM low-dose group,TPM high-dose group,TPM high-dose +FA group ( P <0.01).As compared with that in blank control group,the abnormality rate was obviously increased in TPM high-dose group ( P <0.01),moreover, which in TPM high-dose group was significantly increased , as compared with that in TPM high-dose +FA group ( P <0.05).Conclusion TPM has toxic effect on fetal mice ,however,supplement of folic acid can effectively interfere the effect .