The protective effects of sodium creatine phosphate on the livers’ ALT/LDH of cold preservation in vitro in rats
Abstract：Objective To explore the protective effect of sodium phosphocreatine on rat livers ’ ALT/LDH of cold preservation , with the objective of providing an effective measure for clinical applications .Methods Simple cold preservation from rat liver perfusion model , Application of the experimental group with high , medium and low three different doses of sodium creatine phosphate UW solution and cryopreserved liver perfusion , the control group simplex UW liver perfusion and cryopreservation.Preservation solution was measured at different time points in alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity.Result Different doses of the experimental group after 12h in cold storage,ALT and LDH were lower than the control group .After high dose experimental group after 24h cold preservation,ALT levels were higher in the low dose group.But the experiment found that high doses of the experimental group after group C after 24h cold preservation, ALT levels were higher and the A , B group,considering the drug concentration is too large ,increasing the length time cold preservation of the liver tissue destruction .Conclusions Sodium Phosphocreatine can decreas liver ’ ALT/LDH of cold preservation Significantly ,which has a good protective effect on isolated liver of cold preservation .
Keywords：Rat liver in vitro in ratsALTLDHSodium phosphocreatine
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3696-3698 )