Clinical study on the changes of CD3+4 cells in patients with type 2 diabetes mellitus complicated by terminal stage nephropathy

doi:10.3969/j.issn.1002-7386.2014.23.003

Abstract：Objective To analyze the correlation between CD3+4 cells and the parameters of diabetic nephropathy as well as the pathogenesis of diabetic nephropathy.Methods One hundred patients with terminal stage nephropathy were divided terminal stage nephropathy A group ( with diabetes, n =55 ) and terminal stage nephropathy B group ( without diabetes, n =45),simple diabetes group ( n =50),at the same time,60 healthy subjects were enrolled as control group.The TG,TC,FPG,2 hFPG,HbA1c,ratio of CD3+4 cells/monocytes,urine microcontent albumin,muscle anhydride levels,glomerular filtration rate were detected and comparted in the four groups.Results As compard with that in control group,the ratio of CD3+4 cells/monocytes in three experimental groups were obviously decreased ( P <0.05 ) , which in diabetes group was significantly higher than that in terminal stage nephropathy A group and terminal stage nephropathy B group ( P <0.05) .The ratio of CD3+4 cells/monocytes was negatively correlated to HbA1c, Cr, FPG in terminal stage nephropathy A group ( r =-0.439,-0.241,-0.241,-0.342,-0.298,respectively, P <0.05).Conclusion CD3+4 cells may be risk factors for patients with diabetic nephropathy, which may be involved in the pathiogenesis of diabetic nephropathy, so monitoring the changes of CD3+4 cells may predict the pathogenesis and development of type 2 diabetes mellitus complicated by terminal stage nephropathy,in which diabetes mellitus may result in further decrease of CD3+4 cells.