The expressions and clinical significance of IGFBP-3 and P53 in colorectal cancer

doi:10.3969/j.issn.1002-7386.2014.22.004

Abstract：Objective To investigate the role and clinical significance of IGFBP-3 and P53 in pathogenesis of colorectal cancer (CRC).Methods The expressions of IGFBP-3 and P53 were detected in 138 cases of colorectal cancer tissues and 69 cases of normal colorectal mucosa tissues ( control group ) by immunohistochemistry ( SP ) .Results The positive expression rate (76.8%) of IGFBP-3 in CRC was significantly lower than that (91.3%) in control group ( P <0.05),however,the positive expression rate (53.6%) of P53 in CRC was significantly higher than that (2.9%) in control group ( P <0.05).The expression of IGFBP-3 in CRC was correlated to histological grade,TNM stage and lymph node metastasis ( P <0.05 );the expression of P53 in CRC was correlated to TNM stage, lymph node metastasis and distant metastasis ( P <0.05),but both IGFBP-3 and P53 were not related with the other factors ( P >0.05).Moreover the expression of IGFBP-3 was negatively correlated to that of P53 ( r =-0.27, P <0.01).Conclusion IGFBP-3 and P53 may participate in the invasion and metastasis of CRC,and the two factors have a synergistic effect,combined detection of their expressions in CRC plays an important role in predicting patient’ s prognosis.