Diagnostic significance of pulmonary function test and skin prick test in children with asthma or cough variability asthma

doi:10.3969/j.issn.1002-7386.2014.21.007

Abstract：Objective To explore the diagnostic significance of pulmonary function test and skin prick test ( SPT) in children with asthma or cough variability asthma ( CVA) .Methods Eighty children patients who were diagnosed as asthma or CVA at outpatient department of our hospital from May to November in 2010 were enrolled in the study.They were divided into three groups:asthmatic attack group (group A, n =33),asthma remission group (group B, n =27),CVA group (group C, n=20),and the other 30 healthy children were enrolled as control group.All the children were 5~14 years old.The children in the four groups underwent pulmonary function test to detect the parameters including FVC,FEV1,PEF,FEF25,FEF50 and FEF75,and EOS absolute value in peripheral blood was counted in the four groups.Except for group A,SPT was performed in the other three groups.Results The lung functional parameters ( except for FEV1 in group B and group C) in group A,B,C were significantly lower than those in group D ( P <0.05 or <0.01),moreover,which in group A were obviously lower than those group B and group C ( P <0.01),however,there were no significant differences between group B and group C ( P >0.05).The EOS absolute value in group A,B,C was significantly higher than that in group D ( P <0.05),furthermore,which in group A was obviously higher than that in group C ( P <0.05),however,there was no significant difference between group A and group B and between group B and group C ( P >0.05).The positive rate by SPT was 70.37%(19/27)in group B, 55%(11/20)in group C,and 0 in group D,with total positive rate being 63.83%,there was no significant difference between group B and group C ( P >0.05).The positive rate of SPT was positively correlated to EOS absolute value ( r =0.22, P <0.05).Conclusion Pulmonary function test plays an important role in diagnosis and assessment for children with asthma or CVA,EOS counting and SPT are of great value in the process.