The changes of inflammatory cytokines,re gulatory factor activity and hemorheology in patients with type 2 diabetes mellitus compl ciated by cerebral infarction
Abstract：Objective To investigate the changes of inflammatory cytokines including hs-CRP,IL-6,IL-8,TNF-α,the activity of regulatory factor-NF-κBand hemorheology in patients with type 2 diabetes mellitus complicated by cerebral infarction.Methods A parallel-controlled study was performed in the four groups including control group ( n =60),simple cerebral infarction group ( n =60),simple type 2 diabetes group( n =60),type 2 diabetes with cerebral infarction group ( n=60) .The serum levels of hs-CRP were detected by immunofluorescence assay ,the serum levels of IL6-,IL-8 and TNF-αwere measured by ELISA,and NF-κB activity was detected by immunohistochemistry .The hemorrheology parameters were detected by fully-automatic blood rheometer, and the correlation between NF-κB activity in peripheral blood of patients with type 2 diabetes mellitus complicated by cerebral infarction and hemorrheology parameters were analyzed.Results The serum levels of hs-CRP,IL-6,IL-8,TNF-αand activity of NF-κB in type 2 diabetes with cerebral infarction group were significantly higher than those in the other three groups ( P <0.01).The hemorrheology parameters in type 2 diabetes with cerebral infarction group were significantly higher than those in the other three groups ( P <0.01) .Furthermore,the activity of NF-κB in type 2 diabetes with cerebral infarction group was positively correlated to hemorrheology parameters including whole blood low-shear viscosity,highs-hear viscosity,plasma viscosity,Fib,erythrocyte aggregation index and platelet maximum aggregation rate ( P <0.01).Conclusion The levels of hs-CRP,IL-6,IL-8 and TNF-α are increased by the effect of long-term hyperglycemia, which can activate NF-κB to result in abnormal hemorheology status including high viscosity,hypercoagulability and blood flow slowing,which is easy to form thrombus and induce the pathogenesis and development of type 2 diabetes mellitus complicated by cerebral infarction.Therefore,NF-κB can be used as an new drug target in treating type 2 diabetes mellitus complicated by cerebral infarction.
Keywords：diabetes mellituscerebral infarctioninflammatory cytokinesregulatory factorhemorheology
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3220-3222 )