Expression and clinical significance of chemokine recept or-CXCR4, PTEN in colon mucinous adenocarcinoma
Abstract：Objective To investigate the expression and clinical significance of chemokine receptor-CXCR4,PTEN in colon mucinous adenocarcinoma and to explore the correlation between their expression and cancer invasion,metastasis as well as patient’ s prognosis.Methods The expression levels of PTEN protein and CXCR4 were detected by immunohistochemistry in 20 cases of normal colon tissues, 92 cases of colorectal mucinous adenocarcinoma and the tissues beside cancer.The detection results were contrastively analyzed with clinical data.Results The positive expression rate of PTEN protein in colon mucinous adenocarcinoma was 31.52%(29/92),which in cancer tissue and the tissues beside cancer was significantly lower than that in normal colon tissue ( P<0.05).The positive expression rate of CXCR4 in colon mucinous adenocarcinoma was 61.95%(57/92),which in cancer tissue and the tissues beside cancer was significantly higher than that in normal colon tissue ( P <0.01) .The expressions of PTEN protein and CXCR4 were closely correlated to the infiltration depth of cancer,lymph node metastasis and tumor staging( P <0.05).C onclusion The overexpression of chemokine receptor CXCR4 and PTEN protein are closely related to invasion,metastasis of colon carcinoma,so routine detection of chemokine receptor CXCR4 and PTEN protein is helpful for the treatment of colon mucinous adenocarcinoma.
Keywords：chemokine receptorPTENtissue chipcolon mucinous adenocarcinoma
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3205-3208 )