Clinical significance of serum tumor makers NSE,CA125 in the diagnosis and prognosis assessment of non-Hodgkin’ s lymphoma
Abstract：Objective To investigate the clinical significance of the two serum tumor markers-neuron specific enolase ( NSE) and carbohydrate antigen 125 ( CA-125 ) in the diagnosis and prognosis evaluation of non-Hodgkin ’ s lymphoma ( NHL) .Methods The serum levels of NSE and CA-125 in 56 patients with NHL were measured by electroche miluminescence immunoassay .The correlation between the expressions of NSE , CA125 and clinical characteristics as well as prognosis of patients with NHL were analyzed.Results Before chemotherapy the serum levels of NSE [( 34.63 ± 8.54)μg/L] and CA-125 [(47.59 ±9.53)μg/L] in 56 patients with NHL were significantly higher than those in control group ( P <0.05),furthermore,the expression levels of NSE and CA-125 were correlated with patient ’s symptoms,clinical stage,IPI prognosis index and therapeutic effect.Conclusion The quantitive detection of NSE combined with CA 125 plays an important role in diagnosis,clinical staging and prognosis assessment for patients with NHL ,which can increase diagnostic sensitivity.
Keywords：neuron specigic enolasecarbohydrate antigen 125non-Hodgkin’s lymphomatumor markers
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3051-3053,3054 )