Expression and clinical significance ofC D117,Nestin,CD133 and Ki 67 in epithelial vo arian cancer

doi:10.3969/j.issn.1002-7386.2014.20.001

Abstract：O bjective To investigate the expressions of CD117,Nestin,CD133 and Ki67 in epithelial ovarian cancer (EOC),and to explore the correlation between the expressions and clinicopathologic parameters as well as patient ’s prognosis. Metho ds Eighty paraffin specimens kept in Handan Central Hospital were enrolled in the study ,in which,there were 20 cases of normal ovarian tissues and 60 cases of EOC.The expressions of CD117,Nestin,CD133 and Ki67 were detected by immunohistochemistry ( SP).Results The positive expression rates of CD117, Nestin, CD133 and Ki67in EOC were significantly higher than those in normal ovarian tissues ( P <0.05).The expression levels of CD117,Nestin and CD133 in EOC were correlated to FIGO staging and pathological classification ,which in stageⅢor stageⅣ,G3 were significantly higher than those in stageⅠor stageⅡ,G1 or G2 ( P <0.05).The expression of Ki67 was closely related with differentiation degree of EOC tissues and the expression levels of CA 125 ( P <0.05).The value of detecting CD117,Nestin,CD133 in evaluating the prognosis of patients with EOC could be understand by means of Kaplan-Meier survival curve .Conclusion The positive expressions of CD117, Nestin, CD133 and Ki67 play an important role in the pathogenesis and development of EOC , and CD117,Nestin,CD133 can be used as EOC stem cell markers to evaluate the prognosis of patients with EOC .