Expression and clinical significance of VEGF, P53 in triple negative breast cancer
LI Yansong
Abstract：Objective To investigate the expression and clinical significance of vascular endothelial growth factor (VEGF),P53 in patients with triple negative breast cancer (TNBC).Methods The clinicopathological characteristics in 67 cases of human TNBC and 125 cases of non TNBC ( NTNBC ) were retrospectively analyzed , and the expression levels of VEGF,P53 in the two groups were detected by immunohistochemistry .Results The positive expression rate of VEGF was 70. 1%in TNBC group,which was 32.8%in NTNBC group,there was a significant difference between two groups ( P <0.05). The expression of VEGF was not correlated to patient 's age, tumor size, lymph node metastasis, pathological types and histological classification in TNBC group.The positive expression rate of P53 in TNBC group was 67.2% in TNBC,however, which was 47.2%in NTNBC group,there was a significant difference between two groups ( P <0.05).The expression of P53 was not related with patien's age,tumor size,lymph node metastasis ,pathological types and pathological grading in TNBC group ( P >0.05).Conclusion The TNBC has unique clinicopathological characteristics .The overexpression of VEGF,P53 in TNBC tissues is closely correlated to high malignant degree ,tremendous invasion and poor prognosis ,therefore VEGF and P53 can be used as important reference indexes for evaluating prognosis of patients with TNBC .
Keywords：triple negative breast carcinomavascular endothelial growth factorp53immunohistochemistry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2903-2905 )