The diagnostic value of the serum levels of IGF-1, IGFBP3 and LH in woman children with central precocious ;puberty

doi:10.3969/j.issn.1002-7386.2014.19.006

Abstract：Objective To investigate the changes of serum levels of IGF-1,IGFBP3 and LH in woman children with central precocious puberty (CPP) to provide the theoretical basis for clinical diagnosis and treatment .Methods Sixty-nine woman children with CPP,26 cases of idiopathic central precocious puberty (ICPP),43 cases of simple breast development (SPT) were enrolled in the investigation,meanwhile,30 healthy woman subjects were enrolled as control group .The serum levels of IGF-1,IGFBP3 and LH were detected by electrochemiluminescence method for the four groups .Results The serum levels [(451 ±148)ng/ml] of IGF-1 in ICPP group were significantly higher than those [(268 ±56)ng/ml] in SPT group and those [(141 ±69)ng/ml] in control group ( P <0.05).The serum levels [(268 ±56)ng/ml] of IGF-1 in SPT group were significantly higher than those in control group ( P <0.05).The serum levels [(5.7 ±1.0)ng/ml] of IGFBP3 in ICPP group and those [(5.3 ±0.5) ng/ml] in SPT group were significantly higher than those [(4.2 ±1.3) ng/ml] in control group ( P <0.05).The peak levels [(27.2 ±22.7)U/L] of LH in ICPP group were significantly higher than those [(3.2 ± 1.9)U/L] in SPT group ( P <0.05).Conclusion IGF-1 and IGFBP3 can be regarded as diagnostic basis for diagnosis of sexual precosity ,IGF-1 has the significance of differential diagnosis for ICPP and SPT .The obvious enhancement of LH peak may be correlated to HPG activation in advance of axis function in woman children with CPP .