Expression of GM-CSF in primary and recurrent nasal polyps

doi:10.3969/j.issn.1002-7386.2014.18.006

Abstract：Objective To investigate the expression of granulocyte-macrophage colony-stimulation factor ( GM-CSF) in primary and recurrent nasal polyps . and to explore its effect in the pathogenesis of nasal polyps .Methods The patients were divided into three groups:primary nasal polyps group ( n =40),recurrent nasal polyps group ( n =40),control group (normal inferior concha mucous membrane , n =20),the tissue specimens of inferior concha mucous membrane were from the patients with deflection of nasal septum complicated by hypertrophic inferior turbinate .The expression levels of GM-CSF were detected by immunohistochemistry in three groups ,and the differences of expression were compared between two groups and between females and males in one group .Results The positive cells of GM-CSF expression were mainly located in mucous membrane underlayer and the area around blood vessel , there were significant differences between primary nasal polyps and recurrent nasal polyps ( P <0.05),however,there were no significant differences between females and males in primary nasal polyps group or in recurrent nasal polyps group ( P >0.05).No obvious expression of GM-CSF was found in normal inferior concha mucous membrane tissues .Conclusion GM-CSF can lengthen the survival time of inflammatory cells , inhibit their death and participate in their chemotaxis and infiltration ,which results in the aggregation of a lot of GM-CSF at the area of mucous membrane to promote long-term existence of local inflammation ,as a result,the extent of disease involves gradually whole nasal cavity and many pieces or groups of nasal sinuses to result in the formation and relapse of nasal polyps .