Cell micronucleus detection and analysis for the children with mental retardation
Abstract：Objective To investigate the correlation between chromosome aberration as well as cell micronucleus rate changes and mental retardation in children . Methods Forty children who underwent genetic counseling were enrolled as mental retardation group ,and 20 healthy children were enrolled as control group .The chromosomal numbers and structure in peripheral lymphocytes were analyzed by routine technique of G banding ,and the karyotype and cell micronucleus rate were detected for both groups .Results Among the 40 children with mental retardation , 15 cases of chromosomal abnormal karyotype were found,with the detection rate being 37.5%,in which there were 10 cases (25.0%) of 21-Edwards’ s syndrome,with micronucleus incidence being 12.5%,however,there was 1 case (5.0%) of chromosome abnormality,with micronuclear rate being 3.26%.There were significant differences in the chromosome abnormality incidence and micronucleus rate between two groups ( P <0.01).Conclusion The chromosomal aberration and micronucleus forming are important genetic cause.
Keywords：mental retardationchildrenchromosome aberrationmicronucleus
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2737-2738 )