The expression and significance of nitric oxide synthase positiven eurons in subfornical organ of hypertensive rats GUO
Jianmei
Abstract：Objective To observe the expression and significance of nitric oxide synthase positive neurons in subfornical organ ( SFO) of hypertensive rats .Methods The female Wistar rats were injected with L-nitro-arginine ( L-NNA) 15 mg· d-1 · kg-1 intraperitoneally to establish animal models with hypertension .These rats were randomly were divided into control group,2 -week medication group ,4-week medication group ,8-week medication group , the rats in each group were treated by conventional cardiac perfusion and fixation , then the rats ’ brains were taken out and the paraffin sections were stained with nNOS immunohistochemical staining .Results The immunopositive cells of nNOS within SFO were stained at first deeply,then became shallower with the increase of blood pressure .Conclusion The changes of neuronal nitric oxide synthase immunoreactive neurons in subfornical organ of hypertensive rats may be related with the changes of hypertension ,which may be caused by affecting consensus activity in blood pressure regulation center to regulate indirectly the occurrence of hypertension .
Keywords：subfornical organhypertensionnitric oxide synthaseimmunohistochemistry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2565-2567 )