Correlation between the expression of Ezrin and prognosis in colorectal carcinoma

YAO Dongying; XU Xin; ZHAO Zhenya

doi:10.3969/j.issn.1002-7386.2014.16.002

Abstract：Objective To investigate the expression of Ezrin in colorectal carcinoma and its effect on patient ’ s prognosis.Methods The expression levels of Ezrin were detected by immunohistochemistry in 120 cases of colorectal carcinoma and 20 cases of normal colorectal tissues .Results The positive expression rates of Ezrin were 61.7% and 20.0%,respectively in colorectal carcinoma and normal colorectal tissues ,there were significant differences between them ( P<0.01).The expression of Ezrin in colorectal carcinoma was closely related to tumor differentiation degree ,infiltration depth, lymph node metastasis and Dukes staging ( P <0.05 or P <0.01),however,which was not correlated with patient ’s sex and age,location and size of tumor( P >0.05).The plotted survival curves according to Kaplan-Meier method showed that survival time in patients with negative expression of Ezrin protein was significantly longer than that of patients with positive expression of Eztin protein( P <0.05).Multivariate Cox regression analysis suggested that lymph node metastasis ,Dukes staging and overexpression of Ezrin were independent factors that affected patient ’ s prognosis .Conclusion The overexpression of Ezrin may be involved in development ,invasion,infiltration and metastasis of colorectal carcinoma ,which can be used as one of the indicators of evaluating biological behavior of colorectal carcinoma and patient ’ s prognosis .