The changes of oxidative stress levels of atrial muscle cell and atrial structure remodeling after PD-1 gene knock-out in C57BL/6 mice
Abstract：Objective To investigate the changes of oxidative stress levels of atrial muscle cell and effect on atrial structure remodeling after programmed cell death 1(PD-1) gene knock-out in C57BL/6 mice.Methods The two kinds of mice were enrolled in the study:C57BL/6 control group (15 mice,including 6 males and 9 females ) and C57BL/6-PD-1 group (15 mice,including 6males and 9 females).The oxidative stress levels of atrial muscle cell and atrial myocardial fibrosis were observed for both groups .Results As compared with those in C57BL/6 control group,the oxidative stress levels of atrial muscle cell in PD-1 group were significantly increased ( P <0.05),meanwhile,Masson staining showed that atrial myocardial fibrosis was found in PD-1 group,however,which was not observed in C57BL/6 control group.Conclusion The increase of oxidative stress levels of atrial muscle cell presents after PD-1 gene knock-out in C57BL/6 mice,furthermore,which results in atrial structure remodeling of C57BL/6 mice.
Keywords：PD-1 deficiencyreactive oxygen speciesatrial structure remodelingatrial fibrillation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2256-2258 )