Correlation between the expression l evels of CXXC5 gene and prognosis of patients with acute myeloid leukemia
Abstract：Objecti ev To investigate the expression levels of CXXC 5 gene in patients with acute myeloid leukemia ( AML) ,and to explore its correlation with clinical pathological characteristics .Methods The expression levels of CXXC 5 in 96 patients with AML (AML group) and 19 cases of iron deficiency anemia as well as 5 cases of immune thrombocytopenia (control group) were detected by RQ-PCR.Results The expression levels of CXXC5 gene in AML group were significantly decreased,as compared with those in control group ( P <0.01).The low-expression of CXXC5 gene was found in 44 cases of AML (45.8%).The low-expression rate (86.4%) in AML patients with M1/M2/M3 subtype was significantly higher than that of AML patients with M4/M5/M6 subtype (13.6%, P <0.01 ).The overall survival ( OS) time in AML patients with low-expression of CXXC5 was obviously longer than that of AML patients with non low-expression of CXXC5 ( P <0.01). Conclusion The low-expression of CXXC5 is a common and favorable event in patients with AML , which is favorable to prognosis of AML patients.
Keywords：AMLCXXC5prognosisrealtime quantitative PCR
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2253-2256 )