The change of erythrocty eosmotic fragility and its clinical significance in AMI patients with ST-segment elevation and no reflow after emergency PCI
YE Ming
NIE Shaoping
Abstract：Objective To investigate the change of erythrocyte osmotic fragility in acute myocardial infarction (AMI) patients with ST-segment elevation and no reflow after emergency PCI ,and to explore possible action mechanism and clinical significance .Methods One hundred and twenty AMI patients with ST segment elevation admitted in our hospital were enrolled in the study,in which 60 patients underwent no reflow during emergency PCI (no reflow group),the other 60 patients who did not undergo no reflow were enrolled as control group .The peripheral vein blood 5ml was taken out immediately after hospitalization,then erythrocyte osmotic fragility ,activity of Na +-K+-ATP enzyme on RBC membrane and plasma MDA and SOD levels were detected ,and the action mechanism and clinical significance were analyzed .Results As compared with those in control group,the erythrocyte osmotic fragility was significantly decreased in no flow group ( P <0.01);activity of Na +-K+-ATP enzyme on RBC membrane was obviously reduced ( P <0.05);the plasma levels of MDA significantly increased ( P<0.01),however,the contents of SOD were obviously decreased ( P <0.01).Conclusion The decrease of erythrocyte osmotic fragility in AMI patients with ST segment elevation and no reflow after emergency PCI can reduce red blood cell deformability ,and myocardial microvascular hypoperfusion may be one of the reasons that result in poor prognosis .The reason of erythrocyte osmotic fragility reduction in patients with no reflow may be related with to the decrease of Na +-K+-ATP enzymes activity on red cell membrane and the enhancement of plasma lipid peroxidation .
Keywords：ST-segment elevation acute myocardial infarctionemergency PCIno reflowerythrocyte osmotic fragility
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2250-2252 )