Study on the correlation between BNP and CHF
HAO Xuejun
Abstract：Objective To explore the correlation between plasma levels of brain natriuretic peptide ( BNP ) and chronic heart failure ( CHF) .Methods One hundred patients with left ventricular systolic function failure due to coronary atherosclerosis including 70 males and 30 females (age range: 32 ~78yr) were enrolled as trial group,and the other 100 healthy subjects including 80 males and 20 females (age range:34~58yr) were enrolled as control group .The patients in trial group included 16 cases at gradeⅠ,24 cases at grade Ⅱ,48 cases at grade Ⅲ and 12 cases at grade Ⅳ according to the NYHA classification standard .The plasma levels of BNP were detected by radio immune assay ,left ventricular ejection fraction was determined by Doppler echocardiography , and pulmonary artery pressure ( PAP ) was detected by Swan-Ganz catheter . Resul ts The plasma levels of BNP in trial group were significantly higher than those in control group ( P <0.05).The plasma BNP was negatively correlated to LVEF ( P <0.05),however,which was positively related with PAP ( P <0.05). Conclusion The plasma levels of BNP in patients with left ventricular systolic function failure are increased , which are positively correlated to failure degree;plasma levels of BNP were positivekly related with PAP ,however,which are negatively correlated to LVEF with a linear relationship .
Keywords：brain natriuretic peptidepulmonary artery pressureleft ventricular ejection fractionchronic heart failure
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2091-2093 )