The study on antioxidative system in serum and aqueous humor in patients with diabetic cataract

doi:10.3969/j.issn.1002-7386.2014.13.003

Abstract：Objective To observe the changes of contents of vitamin C ,GSH and MDA in serum and aqueous humor of patients with diabetic cataract ( DC ) , and to explore the relationship between hyperglycosemia with oxidative stress and pathogenesis ,development of diabetic cataract .Methods Thirty-eight cases of diabetic cataract ( DC group ) and 43 cases of age-related cataract without diabetes ( ARC group) and 37 cases of clear lens without diabetes ( control group ) were enrolled in the study.The levels of vitamin C ,GSH and MDA in serum and aqueous humor were detected and compared among three groups.Results As compared with those in control group ,the contents of vitamin C and GSH in serum of DC group and ARC group were significantly decreased ( P <0.05),however,the contents of MDA were obviously increased ( P <0.05).The contents of vitamin C and GSH in serum and aqueous humor of DC group were significantly decreased ,as compared with those in ARC group ( P <0.05).The MDA contents in aqueous humor of DC group were significantly increased by 17.71%,as compared with those in ARC group,but there were no significant differences between two groups ( P >0.05).Conclusion The oxidative stress condition of hyperglycosemia in patients with diabetes mellitus changes the anti -oxidant system of aqueous humor,which may affect metabolism of aqueous humor and crystalline lens ,as a result,accelerate the pathogenesis and development of DC .