Relationship between gene polymorphisms of vitamin D receptor and susceptibility of lung adenocarcinoma
Abstract：Objective To explore the correlation between gene polymorphisms of vitamin D receptor ( VDR) and susceptibility of lung adenocarcinoma .Methods The 172 patients with lung adenocarcinoma ( lung adenocarcinoma group ) and 180 healthy subjects (control group) were enrolled in the study,and all the subjects were Chinese Han people in Hebei province.The correlation between allele polymorphism of Bsm 1,Fok1 site of VDR and lung adenocarcinoma was analyzed by polymerase chain reaction-restriction fragment length polymorphism method .Results There were significant differences in genotype distribution and Bsm 1 genotype distribution of VDR gene between lung adenocarcinoma group and control group (χ2=8.111 and 6.492, P <0.05).However there were no significant differences in genotype distribution and Bsm 1 genotype distribution of VDR gene between lung adenocarcinoma group and control group ( P >0.05).Conclusion Bsm1 gene site polymorphism of VDR gene is closely correlated to pathogenesis risk of advanced lung adenocarcinoma .Bsm1 B allele may increase the pathogenesis risk of lung cancer .Fok1 site polymorphism of VDR may be related with pathogenesis risk of lung cancer.
Keywords：polymorphismsvitamin Dlung neoplasmssusceptibility
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1780-1782 )