Study on the expression of cellular apoptosis-proteins Bcl-2 and Bax expression in oral lichen planus
MAN Yi
ZHONG Liangjun
Abstract：Objective To explore the pathogenesis of oral lichen planus ( OLP) through examining the expression of apoptosis-associated protein Bcl-2 and Bax in OLP .Methods The expression levels and distribution of Bcl-2 and Bax were detected by immunohistochemistry(SP) in 25 cases of normal mucosa and 25 cases OLP tissues.Results As compared with that in normal mucosa,overexpression of Bcl-2 was found in lamina propria and epithelial lining of OLP ( P <0.05),the expression levels of Bcl-2 in lamina propria of OLP were increased with the increase of lymphocyte aggregation dencity ,which were significantly higher than those in epithelial lining of OLP ( P <0.05).The weak expression of Bax in normal mucosa was limited in cuticular layer , however , the expression levels of Bax were increased , as compared with those in normal mucosa , moreover,which were further increased with the aggravation of erosion degree ( P <0.01),and its distribution was more wide. Conclusion The overexpression of Bcl-2 in lamina propria of OLP inhibits apoptosis of lymphocytes and strengthens cellular immunity .The overexpression of Bax is antagonism reaction to epithelial cells and immunocyte of abnormity proliferation ,which try to recover stabilization of cell number and immune balance by inducing cell apoptosis ,however,excess apoptosis can result in erosion,atrophy,skin injury in OLP.
Keywords：oral lichen planusBcl-2Bax
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1623-1626 )