Study on the correlation between FibroScan value and metabolic parameters in patients with nonalcoholic fatty liver
Abstract：Objective Using transient elastography ( FibroScan ) to detect liver stiffness ( E ) and controlled attenuation coefficient ( CAPTM ) in patients with nonalcoholic fatty liver ( NAFL ) , and to explore the correlation between FibroScan value and metabolic parameters .Methods The 729 patients with NAFL ( NAFL group ) and 300 healthy subjects ( control group ) received abdominal ultrasound examination , laboratory examination and FibroScan measurement for E and CAPTM value .Results The clinical parameters in NAFL group were significantly higher than those in control group ( P <0.01).The E value in NAFL group was positively correlated to alanine aminotransferase (ALT),aspartate aminotransferase (AST), CAP, however, which was negatively correlated with total cholesterol ( TC), high density lipoprotein cholesterol (HDL-C)( P <0.01).CAPTM value was positively correlated to triglycerides (TG),fasting blood glucose (FPG),high density lipoprotein cholesterol(HDL-C),hardness(E)( P <0.05).The characteristics in different population had impact on failure rate,failure rate was increased with the increase of BMI ,moreover,the measurement failure rate in the elderly was higher than that in young people ,which in females was higher than that in males ,especially the patients with intercostal space narrow had higher failure rate ( P <0.01).Conclusion FibroScan is currently the only completely non-invasive, painless quantitative tools to evaluate and monitor fatty liver ,without damage to liver ,which has higher sensitivity and accuracy ,and has important value in the diagnosis and regular follow-up in patients with fatty liver .
Keywords：transient elastographynonalcoholic fatty liver
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1611-1614 )