Expression and clinical significance of HMGB1 in ovarian carcinoma
ZHI Hua
MA Haiyan
QU Ruihua
Abstract：Objective To investigate the expression and clinical significance of HMGB 1 in ovarian carcinoma . Methods The expression levels of HMGB1 were detected by immunohistochemistry in 40 cases of ovarian carcinomas ,60 cases of benign ovarian tumors and 30 cases of normal ovarian tissues ,and the expression levels of HMGB 1 were also detected in ovarian carcinoma cells (SKOV3,A2780 and 3AO) by immunohistochemistry.Results As compared with those in benign ovarian tumors and normal ovarian tissues , the expression levels of HMGB 1 in ovarian carcinoma tissues were significantly increased ( P <0.05),moreover,which were closely related with pathological classification ,clinical staging and lymph node metastasis of ovarian carcinoma ( P <0.05),however,which were not correlated to histological type .The expression of HMGB1 was positive in SKOV3,A2780,3AO cells,but there were no significant differences in expression levels among them (P >0.05).Conclusion The expression levels of HMGB1 in ovarian carcinoma are up-regulated,which may be involved in the pathogenesis ,development and metastasis of ovarian carcinoma .
Keywords：ovarian carcinomahigh mobility group box 1immunohistochemistry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1461-1463 )