Study on the hypolipidemic effects of rhubarb and curcuma in experimental mice with hyperlipidemia
YANG Yaoguang
Abstract：Objectives To investigate the effects of single rhubarb ethanol extract , single curcuma ethanol extract , compatibility application on the serum levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) of mice with hyperlipidemia in order to explore the differences of hypolipidemic effects of the two kinds of drugs between single application and compatibility application .Mtehods Seventy male Kunming mice weighted 20~25 g were randomly divided into five groups:control group,model group,rhubarb group, curcuma group,rhubarb +curcuma (1∶1 compatibility) group.The mice in the five groups were given 0.9%sodium chloride solution,fat emulsion,rhubarb ethanol extract suspension ,curcuma ethanol extract suspension ,rhubarb +curcuma (1∶1) ethanol extract suspension,respectively by gavage at the same time ,after 28 days,the blood fat levels were detected for all the mice.Results The single rhubarb ethanol extract ,single curcuma ethanol extract ,compatibility application of two drugs had hypolipidemic effects,as compared with those in control group and model group ( P <0.05).Conclusion The single rhubarb ethanol extract , single curcuma ethanol extract, compatibility application of two drugs can reduce blood fat levels in experimental mice with hyperlipidemia,moreover,the hypolipidemic effect of compatibility application of two drugs (1∶1)is superior to that of single drug extract.
Keywords：rhubarbcurcumacompatibilityblood fat
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1456-1457,1458 )