Expression and significance of cyclins in cervical carcinoma
Abstract：Objective To investigate the expression of human major cyclins (cyclinA,cyclinB,cyclinD1,cyclinE), and to explore the correlation between their expression and radiosensitivity in cervical carcinoma .Methods The expression levels of the four kinds of cyclins were detected by flow cytometry in 42 cases of local advanced cervical carcinoma tissues before radiotherapy and after treatment with 10 Gy radiation.The time for the tumor to diminish a half (T0.5) was calculated every week.The correlation between the expression of the four kinds of cyclins and radiosensitivity (T0.5) was analyzed. Results The positive expression rates of cyclinA ,cyclinB,cyclinD1,cyclinE in cervical carcinoma were 64.2%,83.4%, 57.0%,69.0%,respectively.The T0.5 value in tumors with positive cyclinA and cyclinE was significantly lower ( P <0.05),moreover their radiosensitivities were better .Conclusion The overexpression of cyclinA ,cyclinB,cyclinD1,cyclinE exists in cervical carcinoma ,which can be used as prediction index for evaluating radiosensitivity in cervical carcinoma .
Keywords：cervical carcinomacyclinsradiosensitivityflow cytometry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1448-1450 )